20mg transdermal selegiline daily may be effective and well tolerated in adults with major depression

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20mg transdermal selegiline daily may be effective and well tolerated in adults with major depression.

Setting 6 sites in the United States; timeframe not specified. Participants Participants were 177 outpatients who met the DSM-IV criteria for major depressive disorder (single episode or recurrent) and had no other primary psychiatric diagnosis. Mean age 42 years (range 20–65); 53% women; 93% white. All participants were free of any psychoactive medications for a minimum of 2 weeks prior to tre...

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Selegiline transdermal system in major depressive disorder

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Transdermal selegiline for the treatment of major depressive disorder

Non-selective inhibition of monoamine oxidase (MAO) enzymes (ie, isoforms A and B) in the brain are associated with clinically significant antidepressant effects. In the US, the selegiline transdermal system (STS; EMSAM) is the first antidepressant transdermal delivery system to receive Food and Drug Administration (FDA) approved labeling for the treatment of major depressive disorder (MDD). Cu...

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ژورنال

عنوان ژورنال: Evidence-Based Mental Health

سال: 2003

ISSN: 1362-0347

DOI: 10.1136/ebmh.6.2.44